Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease. Part 3 of 3

Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease – Part 3 of 3

The DBS modus operandi consists of three components: the lead, the extension, and the neurostimulator. The lead (also called an electrode) thin, insulated wire — is inserted through a Lilliputian opening in the skull and implanted in the brain. The tip of the electrode is positioned within the targeted brain area.

The extension is an insulated wire that is passed under the skin of the head, neck, and shoulder, connectng the command to the neurostimulator. The neurostimulator (the “battery pack”) is the third component and is usually implanted under the skin near the collarbone.

In some cases it may be implanted lower in the chest or under the skin over the abdomen. Once the practice is in place, electrical impulses are sent from the neurostimulator up along the extension wire and the lead and into the brain view. These impulses interfere with and block the electrical signals that cause PD symptoms.

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Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease. Part 2 of 3

Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease – Part 2 of 3

Deep brain stimulation (DBS) is a surgical procedure used to treat a variety of disabling neurological symptoms—most commonly the debilitating symptoms of Parkinson’s contagion (PD), such as tremor, rigidity, stiffness, slowed movement, and walking problems. The procedure is also used to treat essential tremor, a common neurological movement disorder.


At present, the policy is used only for patients whose symptoms cannot be adequately controlled with medications. DBS uses a surgically implanted, battery-operated medical device called a neurostimulator—similar to a heart pacemaker and approximately the size of a stopwatch—to distribute electrical stimulation to targeted areas in the brain that control movement, blocking the abnormal nerve signals that cause tremor and PD symptoms.

Before the procedure, a neurosurgeon uses magnetic resonance imaging (MRI) or computed tomography (CT) scanning to specify and locate the exact target within the brain where electrical nerve signals generate the PD symptoms. Some surgeons may use microelectrode recording—which involves a miserly wire that monitors the activity of nerve cells in the target area—to more specifically identify the precise brain target that will be stimulated. Generally, these targets are the thalamus, subthalamic nucleus, and globus pallidus.

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Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease. Part 1 of 3

Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease – Part 1 of 3

Both Medications And Deep Brain Stimulation Surgery May Make Better Life With Parkinson’S Disease. Parkinson’s disorder patients do better if they undergo chasmal brain stimulation surgery in addition to treatment with medication, new research suggests. One year after having the procedure, patients who underwent the surgery reported better quality of life and improved adeptness to get around and engage in routine daily activities compared to those who were treated with medication alone, according to the study published in the April 29 online edition of The Lancet Neurology.

The study authors prominent that while the surgery can provide significant benefits for patients, there also is a risk of serious complications. In deep brain stimulation, electrical impulses are sent into the brain to adjust areas that control movement, according to credentials information in a news release about the research. In the new study, Dr Adrian Williams of Queen Elizabeth Hospital in Birmingham and colleagues in the United Kingdom randomly assigned 366 Parkinson’s condition patients to either receive drug treatment or drug treatment plus surgery.

One year later, the patients took surveys about how well they were doing. “Surgery is likely to last an important treatment option for patients with Parkinson’s disease, especially if the way in which deep brain stimulation exerts its therapeutic benefits is better understood, if its use can be optimized by better electrode placement and settings, and if patients who would have the greatest improve can be better identified,” the authors concluded.

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The Genes Of Autism Spectrum Disorder. Part 3 of 3

The Genes Of Autism Spectrum Disorder – Part 3 of 3

Genes linked to specific psychological and nervous system conditions often are also associated with autism, Croen and Scherer said. For example, in this study, researchers discovered a girl with autism who had a gene kindred primarily to epilepsy, but also to autism. Her brother had a gene related to Angelman’s syndrome, a developmental and neurological disorder that might be linked to autism.

Known autism-risk genes showed up in 42 percent of the families participating in the study. “This may worker explain why autism came about in their child or provide insight into related medical conditions,” Scherer said, noting that in a 2013 pilot genome sequencing study, his duo identified autism-linked genes in more than half of 32 participating families. That study provided several families with medically important information.

Scherer is leading an effort by Autism Speaks, an autism probing and advocacy group, to make the genomes of 10000 families affected by autism publicly available. The genetic data, stored in an open-source database, will hopefully allow researchers more perspicaciousness into the many subtypes of autism and lead to treatments that focus on the individual. Kaiser Permanente also is undertaking similar research gathering medical data and genetic specimens from 5000 people with an autism spectrum fight and their parents natural male enhancement pills free trial. “We need large populations of families with affected and unaffected individuals, to look within those families and across families to see what associates with autism and what doesn’t.

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The Genes Of Autism Spectrum Disorder. Part 2 of 3

The Genes Of Autism Spectrum Disorder – Part 2 of 3

So “We’re saying that’s the wrong matter to do. You need to sequence the whole genome, because more likely than not, it’s going to be something different”. Through such a comprehensive scan, doctors can get children with autism very early treatment, which has been shown to recondition their development. This research relies on “whole-genome sequencing,” a more technologically advanced form of testing that doubles the amount of genetic information produced by each scan.


The cost of such testing has gone down in fresh years as the technology has improved. Scherer’s team sequenced the genetics of 85 four-member families in which both children had been affected by autism. Because autism often runs in families, experts had assumed that siblings with the fracas inherited the same autism-predisposing genes from their parents. Instead, the researchers found that 69 percent of siblings had little to no overlap in the gene variations known to contribute to autism.

Sibling pairs shared the same autism-associated gene changes just 31 percent of the time. Lisa Croen, top banana of the Autism Research Program at Kaiser Permanente Northern California, said she wasn’t too surprised by this finding. “Based on the over research, I would have expected this, because there are so many genes associated with autism but most of these genes are not directly associated with autism. You look across studies and there’s not a lot of consistency which genes are interconnected to autism”.

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The Genes Of Autism Spectrum Disorder. Part 1 of 3

The Genes Of Autism Spectrum Disorder – Part 1 of 3

The Genes Of Autism Spectrum Disorder. Siblings who ration a diagnosis of autism often don’t share the same autism-linked genes, according to a new study. Researchers previously have identified more than 100 genetic mutations that can devise a person more susceptible to an autism spectrum disorder, said senior author Dr Stephen Scherer, director of the Center for Applied Genomics at the Hospital for Sick Children in Toronto. But this mull over revealed that genes linked to autism can vary among family members who would be expected to be genetically similar.

And “We found when we could identify the genes interested in autism, for two-thirds of those families, the children carry different genetic changes. In one-third, the children had the same genetic change and it was inherited from one of the parents”. The study was published online Jan 26, 2015 in Nature Medicine. Autism is a developmental upheaval in which children have trouble communicating with others and exhibit repetitive or obsessive behaviors.

About one in 68 children in the United States has been diagnosed with autism spectrum disorder, according to the US Centers for Disease Control and Prevention. The study’s findings could concrete the way toward more accurate diagnosis and earlier treatment for children with a genetic predisposition toward autism. Previously, if a kind had a child with autism, doctors would focus only on the gene related to that child’s autism in order to predict whether another sibling also could be at risk.

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Glaucoma Is Attacking The US Population. Part 3 of 3

Glaucoma Is Attacking The US Population – Part 3 of 3

To a lesser extent, medical experts also believe that the obesity epidemic will contribute to a rise in glaucoma cases. People with diabetes are twice as likely to realize the potential glaucoma as people without diabetes, although the reasons for that are not clear, according to the foundation.

What is clear, though, is that anyone in a risk group should have regular eye examinations. The National Eye Institute recommends dilated sight exams at least every two years for people at increased risk for glaucoma. “It’s very important to get regular eye exams. Most of us go to the dentist every six months but get our vision checked every 10 years. Which would you rather lose, your observe or your teeth?”

But vision loss need not be a given. Medicines and surgeries available today can slow down the progression of glaucoma. “Vision loss is preventable. Many consumers with glaucoma can enjoy vision for the rest of their lives if the disease is detected early and treated promptly”.

But the key, of course, is finding it early. “A lot of people don’t know that the treatments we have for glaucoma are very good. Just because you have glaucoma, that doesn’t disobliging it’s going to blind you muth marne ke effects. But we have to catch it early”.

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